Symbia Pro.specta SPECT/CT

^99mTc-HIDA sequential planar images demonstrating normal hepatobiliary clearance

• Sequential planar static images following ^99mTc-HIDA administration for evaluation of hepatobiliary transit and gall bladder function
• Study shows normal liver function and biliary clearance
• Normal gall bladder clearance following cholecystokinin (CCK) reflects the adequacy of gallbladder function

SPECT – Symbia Pro.specta 
Scan acquisition: 5-minute static planar anterior view, static images at 5-minute intervals following injection, CCK administered 30 minutes post-injection, 5-minute static acquisition post-CCK at 5-minute intervals for 30 minutes 
Injected dose: ^99mTc Mebrofenin, 4.9 mCi (181.3 MBq)

Tetrofosmin (myocardial perfusion imaging agent) stress myocardial perfusion study shows better ventricular margin definition with respiratory motion correction 

SPECT – Symbia Pro.specta 

Scan acquisition: IQ•SPECT™, step-and-shoot method,16 seconds per stop, 17 stops per detector 

Image reconstruction: stress only, 128 x 128 matrix, OSCGM 48i1s, Gaussian 10 mm, CT attenuation correction (CTAC), breathing motion correction on/off 

Injected dose:  ^99mTc-Tetrofosmin

CT 

Scan parameters: 120 kV/42 ref mAs

Images reconstructed from CT μ-map and SMART Neuro AC doseless μ-map visually similar for SMARTZOOM HRX acquisition 
Relative equivalence in visual assessment of bilateral striatal uptake and stal/occipital contrast between low-energy high-resolution (LEHR), CT attenuation correction (CTAC), and SMARTZOOM^TM HRX (SMART Neuro AC)

SPECT – Symbia Pro.specta
Scan acquisition: 

• LEHR: step-and-shoot method, 40 seconds per view, xSPECT-EM 24i4s, Gaussian 10 mm  
• SZHRX: dynamic tomo, 10 cycles with 2 detectors x 60 projections, 4 seconds per view, xSPECT-EM 18i4s, Gaussian 10 mm 

Calculated AC threshold: 2% 
Injected dose: 123I-123 Ioflupane

CT
Scan parameters: 110 kV/24 ref mAs

Sequential xSPECT Quant study following therapeutic administration of ¹⁷⁷Lu-DOTATATE enables dosimetry

• Sequential SPECT/CT with xSPECT Quant™ following large-dose ¹⁷⁷Lu-DOTATATE therapy in a patient with a metastatic NET shows gradual increase in tracer concentration in liver metastases with peak at 24 hours with slow washout shown on the 168-hour study 
• Renal cortical tracer concentration shows initial high uptake with progressive washout 

SPECT – Symbia Pro.specta 
Scan acquisition: 2 bed positions/60 stops per detector, 20 seconds per stop 
Image reconstruction: 128 x 128 matrix, OSCGMM 24i4s
Injected dose:¹⁷⁷Lu-DOTATATE, 7.7 GBq (200 mCi)
Post-injection delay: 4 and 24 hours 

CT 
Scan parameters: 130 kV/40 ref mAs, 0.33-sec rotation, 32 x 0.7 mm collimation, 4 mm recon, BR31s

SPECT/CT shows leukocyte accumulation in stabilization screws of an intramedullary rod inserted for femoral fracture

• Patient with bilateral femoral intramedullary rod insertion secondary to fracture 
• ^99mTc-labeled white blood cell (WBC) SPECT/CT shows focal accumulation of radiolabeled-WBCs at the insertion of the upper stabilization screw into the right intramedullary rod suggestive of infection at screw insertion 
• CT with iMAR² eliminates metal artifacts related to the stabilization pin for clear visualization and localization of hypermetabolism at pin insertion

SPECT – Symbia Pro.specta 
Scan acquisition: 60 stops per detector, 20 seconds per stop 
Image reconstruction: 128 x 128 matrix, OSEM3D 5i15s
Injected dose: ^99mTc HMPAO-labeled leukocytes, 8.91 mCi (330 MBq) 
Post-injection delay: 2 hours 

CT 
Scan parameters: 110 kV/150 ref mAs, 0.33 sec rotation, 32 x 0.7 mm collimation, 1 mm recon, BR44 S3 iMAR