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Reproductive Endocrinology Assays
New sFlt-1 and PlGF assays to aid in the prognosis of preeclampsia

High performing reproductive endocrinology assays

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Preeclampsia (PE) is a type of hypertensive disorder of pregnancy characterized by high blood pressure, and proteinuria. PE occurs in 2–8% of pregnancies and potentially contributes to significant fetal, neonatal, and maternal morbidity and mortality.1 The addition of the Siemens Healthineers sFlt-1 and PlGF assays, prognostic markers for preeclampsia, will help to improve the management of this condition. 

Epidemology
Atellica® IM sFlt-1

Atellica® IM sFlt-1 and PlGF Performance Characteristics

Robust analytical performance

  • LoB: sFLT 2 pg/mL and PlGF 3 pg/mL
  • LoD: sFlt 10 pg/mL and PlGF 6 pg/mL
  • LoQ: sFlt 13 pg/mL and PlGF 9 pg/mL

Broad measuring range

  • sFlt: 15 -- 85,000 pg/mL
  • PlGF: 9 -- 10,000 pg/mL

Atellica® IM sFlt-1

sFlT-1/PIGF (PE) ratio verified based on clinical agreement of results from clinical studies

  • Cut-off value of sFlt-1/PlGF ≥ 38 at 20+0 – 35+6 (weeks + days) gestational age indicates an increased risk of adverse maternal/fetal outcomes or preterm delivery within 2 weeks

Clinical performance of PE ratio using a cut-off value of 38

  • 88.42% sensitivity (95%CI = 81.99-94.86%)
  • 87.65% specificity ( 95%CI = 83.52-91.79%)
  • 73.68% positive predictive value (95%CI = 65.60‒81.77%)
  • 95.09% negative predictive value (95%CI = 92.26‒97.92%)

Reproductive Care for a Lifetime

Reproductive Care for a Lifetime

Reproductive endocrinology covers a wide range of endocrine disorders related to the reproductive system in both males and females, including puberty and menstrual cycles, infertility, pregnancy, and menopause. As a longstanding leader in reproductive endocrinology, Siemens Healthineers offers a broad range of systems and assays to address the various clinical needs in reproductive health.
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1

American College of Obstetrics and Gynecology (ACOG) Practice Bulletin No. 222: Obstet Gynecol 2020;135:e237-e260

August et al. UpToDate 2019 Preeclampsia: Clinical features and diagnosis

Lisonkova S, et al. Obstet Gynecol 2014;124:771-81.

World Health Report: Women's and Children's Health. In: WHO, ed. Geneva, Switzerland. 2005

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