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      High-Sensitivity Troponin I Assay

      Fast, Accurate, Actionable Results When it Matters Most

      High-Sensitivity Troponin I Assay

      Proven, true high-sensitivity troponin I assays with improved sensitivity and precision at the low end of the assay range.

      Join Us! High-Sensitivity Troponin I Live Event

      Perspectives in 2020 Successfully Implementing High-Sensitivity Cardiac Troponin: Collaboration Between Laboratory Medicine and Clinical Practice

      Designed to aid in diagnosing acute myocardial infarctions (AMI) through the quantitative measurement of cardiac troponin I in serum or plasma, high-sensitivity troponin plays a critical role in the timely diagnosis of AMI, or heart attacks.

      Siemens Healthineers offers proven, true high-sensitivity cardiac troponin I assays:

      • Demonstrate clinical proof that the Siemens Healthineers’ assays are true high-sensitivity troponin I assays according to current guidelines.1-4
      • Offer fast, accurate, and actionable results to leverage current protocols
      • Provide confidence in results due to minimal assay interferences*
      The Atellica® Solution’s streamlined STAT process has been shown to deliver actionable high-sensitivity troponin I results in 10 minutes.

      The Atellica® Solution’s streamlined STAT process has been shown to deliver actionable high-sensitivity troponin I results in 10 minutes.

      Trusted Results Across Systems

      Siemens Healthineers is proud to offer high-sensitivity troponin I across multiple systems, including the Atellica® IM Analyzer, ADVIA Centaur® System, Dimension® EXL™ Integrated Systems, and Dimension Vista® Intelligent Lab Systems.

      TNIH Flowchart

      4th Universal Definition of Myocardial Infarction White Paper 

      Download this Guide for Laboratorians Today

      A new white paper summarizes the criteria for clinical definitions of myocardial infarction, with a focus on content relevant to the laboratorian.

      • Learn about the analytical issues of high-sensitivity cardiac troponin assays
      • Know the benefits of high-sensitivity cardiac troponin assays
      • Understand how to use faster protocols for acute myocardial injury diagnosis  

      Laboratory and Clinical Perspectives: 

      Understanding Findings of Sex-specific 99th Percentile URLs for High-sensitivity Cardiac Troponin Assays Derived from Universal Sample Bank

      Earn CE credits!

      Selection of healthy reference populations and definition of exclusion criteria for deriving 99th percentiles for high-sensitivity cardiac troponin assays (hs-cTn) used in clinical practice and research vary considerably. Dr. Fred S. Apple and Dr. W. Frank Peacock discuss the following Universal Sample Bank findings and their clinical implications:

      • Sex-specific 99th percentiles varied according to the statistical method and hs-cTn assay used
      • Not all assays provided measurable concentrations for women to qualify as hs assays
      • Surrogate exclusion criteria used to define normality tended to lower 99th percentiles
      • Participants will learn that the decision concentrations used can affect diagnostics, risk-outcome assessments, and analytical characteristics.  

      Receive a complementary copy of the Clinical Chemistry article “Sex-Specific 99th Percentile Upper Reference Limits for High Sensitivity Cardiac Troponin Assays Derived Using a Universal Sample Bank.”

        Successful Conversion to a High-Sensitivity Troponin I Assay 


        New AACC Poster #B-17

        A large clinical laboratory in France recently transitioned from a contemporary sensitive cardiac troponin I assay to a high-sensitivity troponin I assay. To support the successful introduction of high-sensitivity troponin, the lab collaborated in advance with clinicians to help educate them on the improved clinical utility of a high-sensitivity test compared to the existing sensitive cTnI assay. Evaluating the performance of the new method in close collaboration with clinicians helped the laboratory provide critical support to clinicians during the assay conversion. 

        1

        Apple F., Sandoval Y., Jaffe A., and Ordonez-Llanos J. Cardiac Troponin Assays: Guide to Understanding Analytical Characteristics and Their Impact on Clinical Care. Report of the IFCC Task Force on Clinical Applications of Cardiac Biomarkers. Clinical Chemistry 63:01 (2016)

        2

        Alan H.B. Wu, Clinical Chemistry 64:4 645–655 (2018)

        3

        European Heart Journal (2018) 00, 1–33 EXPERT CONSENSUS DOCUMENT Circulation. 2018;138:00–00. DOI: 10.1161/CIR.0000000000000617

        4

        European Heart Journal 2020 00, 179 ESC GUIDELINESdoi:10.1093/eurheartj/ehaa575 

        *Atellica IM TnIH & ADVIA Centaur TNIH assays: Biotin interference demonstrating less than 10% change in results up to 3500 ng/mL.