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    3. Staying Ahead of Cytokine Storm

    ​Staying Ahead of Cytokine Storm​

    Testing for Key Inflammation Markers

    Why do some patients with COVID-19 experience milder symptoms and others experience more severe symptoms?​ Cytokine storm (CS) is an extreme immune response associated with severe COVID-19 disease. ​

    Cytokine Storm

    The role of IL-6 in COVID-19 Testing

    Interleukin-6 (IL-6) is an early indicator of inflammatory response to illness or injury. An important mediator of the immune response to pathogens, IL-6 is a member of the cytokine class of chemical messengers that induces both pro- and anti-inflammatory responses. It plays a significant role in the development and escalation of CS in COVID-19 patients.2-4

    Cytokine Storm

    Cytokine Storm Infographic

    Of severe COVID-19 patients, approximately 5% develop a systemic dysregulated cytokine response.1,5 This extreme immune response, called cytokine storm, is associated with severe COVID-19 disease and can cause widescale cellular and organ tissue damage.

    Webinar – COVID-19 and Cytokine Storm

    In the most severe COVID-19 cases patients can develop a dysregulated cytokine inflammatory response to the infection. Upon further evaluation, IL-6 is thought to be the central regulator of the cytokine response and cytokine storm. Learn about the challenges healthcare providers face treating patients with COVID-19 and the dangers of the cytokine storm response. You will also learn how elevated IL-6 is associated with a higher risk of progressing to a severe disease in COVID-19 patients.

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    1

    Siddiqi HK, et al. J Heart Lung Transplant. 2020. https://doi.org/10.1016/j.healun.2020.03.012.

    2

    Shimizu M. Clinical Features of Cytokine Storm Syndrome. In: Cron GR, Behrens EM, editors. Cytokine storm syndrome. Springer Nature Switzerland AG; 2019. https://doi.org/10.1007/978-3-030-22094-5

    3

    Mahmud-Al Rafat A, Majumder A, Rahman T, et al. Decoding the enigma of antiviral crisis: Does one target molecule regulate all? Cytokine. 2019;115:12-23.

    4

    Liu T, Zhang J, Yang Y, et al. The potential role of IL-6 in monitoring coronavirus diseases 2019. The Lancet. 2020. DOI: 10.2139/ssrn.3548761.

    5

    Zhou Y, et al. National Science Review. 2020. DOI: 10.1093/nsr/nwaa041

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